This week’s Bad News Good News

STEPHEN CHERNISKE·WEDNESDAY, NOVEMBER 18, 2015
httpwww.freedigitalphotos.netimagesagree-terms.phpid=100217596As you probably know, there is a worldwide epidemic of chronic kidney disease (CKD), caused primarily by high blood pressure and diabetes. Now there is a related factor. A study published in the journal Hypertension found that people using NSAIDS (Non-Steroidal Anti-Inflammatory Drugs) were at significantly increased risk for CKD. [1]

Interestingly, the researchers did not suggest that people with hypertension find an alternative way to deal with their inflammation and pain (they exist) but instead, advised doctors to watch kidney function carefully in patients using NSAIDS. What good is that, since the damage that occurs is rarely reversible.
Even worse, of course is the reality that 50% of people with hypertension don’t know it, and chronic use of NSAIDS is extremely common.
Common NSAIDS include:

  • aspirin
  • celecoxib (Celebrex)
  • ibuprofen (Motrin, Advil)
  • indomethacin (Indocin)
  • diclofenac (Cambia, Cataflam, Voltaren-XR, Zipsor, Zorvolex)
  • naproxen (Aleve, Anaprox, Naprelan, Naprosyn)
  • sulindac (Clinoril)
  • diflunisal (Dolobid )
  • etodolac (Lodine)
  • ketoprofen (Active-Ketoprofen)
  • ketorolac
  • nabumetone (Relafen)
  • oxaprozin (Daypro)
  • piroxicam (Feldene)
  • salsalate (Disalsate)
  • tolmetin (Tolectin)

And now some good news. Actually there’s plenty of good news regarding the health benefits of polyphenol-rich fruits like blueberries, cranberries and concord grapes. The polyphenols in green tea and cocoa also appear to have remarkable health benefits. The range of benefits studied include brain health, heart health, blood sugar balance and anti-aging. [2,3.4] One of my favorites is a test-tube study that identified the genomic pathway by which a blueberry concentrate accelerated DNA repair.[5] This is an important factor in longevity research, since DNA damage is considered the “universal” cause of death. In other words, if you don’t die of a disease or an accident, you will ultimately die of cumulative (and non-repairable) DNA damage. Now there are proven ways to dramatically alter the way you experience the aging process.
Onward!

References:
[1] Hsu CC, Wang H, Hsu YH, et al. Use of Nonsteroidal Anti-Inflammatory Drugs and Risk of Chronic Kidney Disease in Subjects With Hypertension: Nationwide Longitudinal Cohort Study. Hypertension. 2015 Sep;66(3):524-33.
[2] Uysal U, Seremet S, Lamping JW, Adams JM, Liu DY, Swerdlow RH, Aires DJ. Consumption of polyphenol plants may slow aging and associated diseases. Curr Pharm Des. 2013;19(34):6094-111.
[3]. Guo H, Cao M, Zou S, Ye B, Dong Y. Cranberry Extract Standardized for Proanthocyanidins Alleviates β-Amyloid Peptide Toxicity by Improving Proteostasis Through HSF-1 in Caenorhabditis elegans Model of Alzheimer’s Disease. J Gerontol A Biol Sci Med Sci. 2015 Sep 23. pii: glv165.
[4] Koupý D, Kotolová H, Kučerová J. Effectiveness of phytotherapy in supportive treatment of type 2 diabetes mellitus Billberry (Vaccinium myrtillus). Ceska Slov Farm. 2015 Spring;64(1-2):3-6.
[5] Liu W1, Lu X, He G, Gao X, Xu M, Zhang J, Li M, Wang L, Li Z, Wang L, Luo C. Protective roles of Gadd45 and MDM2 in blueberry anthocyanins mediated DNA repair of fragmented and non-fragmented DNA damage in UV-irradiated HepG2 cells. Int J Mol Sci. 2013 Oct 30;14(11):21447-62.

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